Recent advances in IVF treatment!

Recent advances in IVF treatment!

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Innovations in IVF treatments continue in parallel with dizzying rapid developments in medicine. For sperm selection, IMSI, Embryoscope monitoring of embryos second by second, examining the genetic structure of embryos are just a few of them biri One of every 10 couples in our country is having problems. Parallel to the developments in the field of medicine, new hopes are emerging day by day in IVF treatments. Bahçeci Health Group Umut IVF Center Gynecology and Obstetrics Specialist Assoc. Contact ulun directly gives information about the latest developments.

What is the IMSI method for sperm selection?

In IVF treatments, sperms are selected under a special microscope and injected into the egg by microinjection method. During this process, it is necessary to ensure that the moving tail and head shape of the sperm is smooth in order to obtain a quality embryo. Bahçeci Health Group Umut IVF Center Gynecology and Obstetrics Specialist Assoc. Ulun Uluğ gave the following information about the IMSI method regarding sperm selection: olduğunda We think that we have found a healthy sperm when the shape characteristics of the sperm called morphology are good. Microscopes, which are conventionally used for microinjection, help sperm selection by increasing the sperm up to 400 times. Intra-ctoplasmic magnified sperm injection (IMSI), a special lens and computer program is used to enlarge the sperm up to 6600 times. In this way, the morphology of sperm is better evaluated. Specifically, changes in the head of the sperm determine the quality of the sperm and attention is paid to the cellular changes in the bubble shape in this region. IMSI is not only related to the microscope, but it is also important that the embryologist using this method is trained and experienced. By choosing healthier sperms, both fertilization rates and pregnancy rates were improved. It is especially preferred in cases of male factor or unexplained infertility.

How are embryos monitored in laboratory conditions?

The most sensitive part is to store and monitor the embryos obtained during IVF treatment in laboratory conditions. Associate Professor. Ulun Uluğ said: “Laboratory conditions should be no different from the mother's womb. For this purpose, many mediums called culture medium that provide maternal uterine environment has been developed. However, there are devices called an incubator that maintain a constant temperature and mimic the proportion of gases in the mother's abdomen such as oxygen and carbon dioxide. These devices must be very sensitive. Embryos are kept in these devices for 2 to 5 days and should not be damaged during this period. The important issue here; the development of embryos - to decide which embryo to transfer. For this purpose, the embryos are removed from the incubator at certain intervals and examined under a microscope and their growth rates are evaluated. Embryos, which reach to room temperature in a short time, are exposed to external world conditions. From this point, the embryos are monitored without being taken out by the cameras placed in the incubator just like someone is spying on us and they are not exposed to the outdoor conditions. The 'Embryooscope', which we call 'Dynamic Embryo Tracking System', is used to understand which embryo has the most potential for growth, both when the embryos are stored in the best rams and they are under constant observation. Embryoscope helps us to identify many developmental problems that we have not noticed before. In other words, we can see the history of an embryo more clearly. When we select embryos with a proper history, our pregnancy rates increase. ”

How to better understand the genetic structure of embryos?

Embryos are composed of similar cells. Associate Professor. Ulun Uluğ said that all embryos obtained after treatment are not of the same quality and that the most important problem is the differences in their genetic structure, especially chromosome numbers, and continued: “This risk increases especially in older women. In the last 15 years, the genetic structure of the embryos has been examined by PGD. Recurrent pregnancy losses, unsuccessful IVF treatments and hereditary discomfort in the family is a method applied. However, in this method, not all 23 pairs of chromosomes were normally looked at. The most important problem here was that the genetic analysis was performed quickly within 1 night and the healthy embryo was transferred the next day. In this context, due to limited time and technical difficulties, not all chromosomes could be looked at. In recent years, all chromosomes can be screened by using the method called genetik Comparative Genetic Hybridization (CGH) embr and embryos with a healthy genetic structure can be extracted. Even if it has not yet been fully established in clinical practice, CGH will soon be used, especially for patients with recurrent IVF failure. ”

Is it possible to avoid being injected every day in IVF treatment?

The aim of the doctors during treatment is to ensure that a large number of eggs are formed and that a large number of embryos are developed to extract them. Associate Professor. Ulun Uluğ said: olduğunda When there is a large number of embryos, the remaining ones can be frozen and the patients can be given a second chance with a simple method. We do not give more drugs and do not create a large number of eggs in the past, but we recommend our patients to make injections from their bellies or hips every day. Thanks to these drugs, the eggs grow. In an already psychologically challenging treatment, going to a healthcare facility in order to have injections or needles every day is an additional burden. Since the life of the drugs used in the body is short, these drugs should be given at short intervals. For the last 2 years, daily injections are no longer necessary with a new drug applied especially in Northern European countries. Single dose injection lasts up to 1 week and is a patient-friendly treatment. It is very likely that similar drugs will be available in our country at the beginning of next year and there will no longer be need for continuous injections that scare patients in IVF treatments. Naturally, each innovation brings more success, in other words, more pregnancy. However, we also need to bear in mind that sometimes the changes we see as innovations do not bring much success. ”

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